Naive T Cells in Graft Versus Host Disease and Graft Versus Leukemia: Innocent or Guilty?

Naive T Cells in Graft Versus Host Disease and Graft Versus Leukemia: Innocent or Guilty?

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The outcome of allogeneic hematopoietic cell transplantation (allo-HCT) largely depends on the development and management of graft-versus-host disease (GvHD), infections, and the occurrence of relapse of malignancies.Recent studies showed a lower incidence of chronic GvHD and severe acute GvHD in patients receiving naive T cell depleted grafts compared to patients receiving complete T cell depleted grafts.On the other hand, the incidence of acute GvHD in patients receiving cord blood grafts containing only naive T cells is rather low, while potent graft-versus-leukemia (GvL) responses have been observed.These data suggest the significance of naive T cells as both drivers and regulators of allogeneic reactions.

The naive T cell pool was Faber High-Light RAD BRS WH MATT A91 Matt White 91cm 110.0456.206 cooker hood previously thought to be a quiescent, homogenous pool of antigen-inexperienced cells.However, recent studies showed important differences in phenotype, differentiation status, location, and function within the naive T cell population.Therefore, the adequate recovery of these seemingly innocent T cells might be relevant in the imminent allogeneic reactions after allo-HCT.Here, an extensive review on naive T cells and their contribution to the development of GvHD and GvL responses after allo-HCT is provided.

In addition, strategies specifically directed to stimulate adequate reconstitution of naive T cells while reducing the risk of GvHD are discussed.A better understanding of the relation between naive T cells and alloreactivity after allo-HCT could provide opportunities NEFF B47FS34H0B Built In Slide to improve GvHD prevention, while maintaining GvL effects to lower relapse risk.